ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Familial tauopathy with P364S MAPT mutation : clinical course, neuropathology and ultrastructure of neuronal tau inclusionsŠtrafela, Peter ...Aims: This report presents the clinical course, neuropathology and ultrastructure of neuronal tau inclusions of four Slovene relatives with P364S MAPT mutation. Methods: The clinical history of three ... out of four P364S MAPT mutation carriers was taken. After formalin fixation, thorough sampling of the central nervous system was followed by paraffin embedding, H&E, Gallyas, Bielschowsky and immunostaining with AT8, anti-3R, anti-4R tau, anti-amyloid-%, anti-TDP43 and anti-alpha-synuclein antibodies. The distribution and density of different types of neuronal tau inclusions were semiquantitatively assessed. In addition, the ultrastructure of neuronal tau inclusions was analysed. Results: Macroscopic examination of the brains was unremarkable. Microscopically, neuronal tau inclusions of almost all known types were widespread and distributed fairly uniformly in all cases. Pick bodies and swollen neurones were found in only one family member. Mutant tau was composed of 3R and 4R isoforms, with a slight predominance of 3R tau. Composite neuronal tau inclusion (CNTI), found in all four relatives, was a hallmark of the P364S MAPT mutation. CNTI showed compartmental differences in H&E and Gallyas staining, tau isoforms immunolabelling and ultrastructure, displaying fuzzy fibrils in the core and paired twisted tubules at the periphery. Conclusions: P364S MAPT mutation is characterized clinically by a variable combination of frontotemporal dementia, parkinsonism and motor neurone disease of short duration, and neuropathologically by a widespread uniform distribution of all known neuronal tau inclusions in one family member. Two-compartment CNTI is a unique characteristic of the P364S MAPT mutation.Source: Neuropathology and applied neurobiology. - ISSN 0305-1846 (Vol. 44, iss. 6, 2018, str. 550-562)Type of material - article, component partPublish date - 2018Language - englishCOBISS.SI-ID - 33623513
Author
Štrafela, Peter |
Pleško, Jerica |
Magdič, Jožef, 1975- |
Koritnik, Blaž, 1973- |
Zupan, Andrej, 1981- |
Glavač, Damjan |
Bresjanac, Mara |
Popović, Mara
Topics
motor neurone disease |
parkinsonism |
composite neuronal tau inclusion |
bolezen motoričnih nevronov |
parkinsonizem |
sestavljena nevronska tau vključitev
![loading ... loading ...](themes/default/img/ajax-loading.gif)
source: Neuropathology and applied neurobiology. - ISSN 0305-1846 (Vol. 44, iss. 6, 2018, str. 550-562)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Štrafela, Peter | ![]() |
Pleško, Jerica | 36130 |
Magdič, Jožef, 1975- | 55523 |
Koritnik, Blaž, 1973- | 21239 |
Zupan, Andrej, 1981- | 28143 |
Glavač, Damjan | 09275 |
Bresjanac, Mara | 10428 |
Popović, Mara | 07090 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: