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Sinteza 3-ketopalmitoil koencima A : [Prešernove nagrade študentom]Košak, Urban17ß-hidroksisteroid-dehidrogenaza tipa 12 je encim, ki sodi v družino 17ß-hidroksisteroid-dehidrogenaz in katalizira redukcijo estrona v estradiol. Poleg vloge pri steroidogenezi naj bi imel vlogo ... tudi pri presnavljanju lipidov. Kataliziral naj bi redukcijo 3-ketoacil koencima A v 3-hidroksiacil koencim A. Ta redukcija je druga stopnja mikrosomalnega podaljševanja maščobnih kislin. S sintezo potencialnega endogenega substrata, 3-ketopalmitoil koencima A, bi prispevali k raziskovanju potencialne multifunkcionalnosti tega encima in s tem k razvoju novih učinkovin za nekatera rakava obolenja, motnje presnove in različne genetske ter nevrodegenerativne bolezni, s katerimi so povezane 17ß-hidroksisteroid-dehidrogenaze. Ker smo za sintezo 3-ketopalmitoil koencima A potrebovali etil 3-oksoheksadekanoat, smo razvili enostaven postopek za sintezo Ž,Ž-nesubstituiranih in Ž-monosubstituiranih Ž-keto estrov iz kislinskih kloridov in etil acetoacetata. S tem postopkom smo sintetiziralietil 3-oksooktanoat, etil 3-okso-3-fenilpropanoat, etil 3-(4-nitrofenil)-3-oksopropanoat, etil 3-(4-klorofenil)-3-oksopropanoat in etil 3-oksoheksadekanoat, ki smo ga uporabili za sintezo 3-ketopalmitoil koencima A. Sinteza končne spojine 3-ketopalmitoil koencima A je bila mogoča le z uvedbo zaščitne skupine za Ž-karbonilno skupino. Za določanje čistosti 3-(1',3'-dioksolanil)palmitoil koencima A in 3-ketopalitoil koencima A ter spremljanje poteka pretvorbe 3-(1',3'-dioksolanil)palmitoil koencima A v 3-ketopalitoil koencima A smo razvili več HPLC metod.Type of material - research projectPublication and manufacture - Ljubljana : [Košak U.], 2012Language - slovenianCOBISS.SI-ID - 3362673
Author
Košak, Urban
Other authors
Gobec, Stanislav, 1970- |
Kovač, Andreja, farmacevtka, 1979-
Topics
3-ketopalmitoil koencim A |
17ß hidroksiteroid dehidrogenaza |
ß-ketoestri |
sinteza |
retrosintezna analiza |
HPLC metode
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Košak, Urban | 33908 |
Gobec, Stanislav, 1970- | 15284 |
Kovač, Andreja, farmacevtka, 1979- | 27782 |
Source: Personal bibliographies
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