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Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seqFilbin, Mariella G. ...Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and ... cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority. OPC-like cells exhibit greater proliferation and tumor-propagating potential than their more differentiated counterparts and are at least in part sustained by PDGFRA signaling. Our study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.Source: Science. - ISSN 0036-8075 (Vol. 360, iss. 6386, Apr. 2018, str. 331-335)Type of material - article, component part ; adult, seriousPublish date - 2018Language - englishCOBISS.SI-ID - 33745625
Author
Filbin, Mariella G. |
Tirosh, Itay |
Horvestadt, Volker |
McKenzie, Shaw L. |
Escalante, Leah E. |
Mathewson, Nathan D. |
Neftel, Cyril |
Frank, Nelli |
Pelton, Kristine |
Popović, Mara
Topics
gliomi |
centralni živčni sistem |
genski subkloni |
gliomas |
central nervous system |
genetic subclones
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Filbin, Mariella G. | |
Tirosh, Itay | |
Horvestadt, Volker | |
McKenzie, Shaw L. | |
Escalante, Leah E. | |
Mathewson, Nathan D. | |
Neftel, Cyril | |
Frank, Nelli | |
Pelton, Kristine | |
Popović, Mara | 07090 |
Source: Personal bibliographies
and: SICRIS
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