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Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAMEDrmić, Domagoj ...Aim To counteract/reveal celecoxib-induced toxicity and NO system involvement. Methods Celecoxib (1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157 (known to ... inhibit these lesions, 10 [micro]g/kg, 10 ng/kg, or 1 ng/kg ip) and L-arginine (100 mg/kg ip), as well as NOS blockade [N(G)-nitro-L-arginine methyl ester (L-NAME)] (5 mg/kg ip) given alone and/or combined immediately after celecoxib. Gastrointestinal, liver, and brain lesions and liver enzyme serum values in rats were assessed at 24 h and 48 h thereafter. Results This high-dose celecoxib administration, as a result of NO system dysfunction, led to gastric, liver, and brain lesions and increased liver enzyme serum values. The L-NAME-induced aggravation of the lesions was notable for gastric lesions, while in liver and brain lesions the beneficial effect of L-arginine was blunted. L-arginine counteracted gastric, liver and brain lesions. These findings support the NO system mechanism(s), both NO system agonization (L-arginine) and NO system antagonization (L-NAME), that on the whole are behind all of these COX phenomena. An even more complete antagonization was identified with BPC 157 (at both 24 h and 48 h). A beneficial effect was evident on all the increasingly negative effects of celecoxib and L-NAME application and in all the BPC 157 groups (L-arginine + BPC 157; L-NAME + BPC 157; L-NAME + L-arginine + BPC 157). Thus, these findings demonstrated that BPC 157 may equally counteract both COX-2 inhibition (counteracting the noxious effects of celecoxib on all lesions) and additional NOS blockade (equally counteracting the noxious effects of celecoxib + L-NAME). Conclusion BPC 157 and L-arginine alleviate gastrointestinal, liver and brain lesions, redressing NSAIDs' post-surgery application and NO system involvement.Source: World Journal of Gastroenterology = Shijie Wei-Changbingxue Zazhi. - ISSN 1007-9327 (Vol. 23, iss. 29, Aug. 2017, str. 5304-5312)Type of material - article, component partPublish date - 2017Language - englishCOBISS.SI-ID - 34167769
Author
Drmić, Domagoj |
Kolenc, Danijela |
Ilić, Spomenko |
Bauk, Lara |
Sever, Marko, 1981- |
Zenko Sever, Anita |
Luetic, Kresimir |
Suran, Jelena |
Seiwerth, Sven |
Sikirić, Predrag
Topics
BPC 157 |
celecoxib |
L-arginine |
BPC 157 |
celekoksib |
L-arginin
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source: World Journal of Gastroenterology = Shijie Wei-Changbingxue Zazhi. - ISSN 1007-9327 (Vol. 23, iss. 29, Aug. 2017, str. 5304-5312)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Drmić, Domagoj | ![]() |
Kolenc, Danijela | 52857 |
Ilić, Spomenko | ![]() |
Bauk, Lara | ![]() |
Sever, Marko, 1981- | ![]() |
Zenko Sever, Anita | ![]() |
Luetic, Kresimir | ![]() |
Suran, Jelena | ![]() |
Seiwerth, Sven | ![]() |
Sikirić, Predrag | ![]() |
Source: Personal bibliographies
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