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Effects of ibogaine per os application on redox homeostasis in rat liver and erythrocytesVidonja-Uzelac, Teodora ...Ibogaine, administered as a single oral dose (1-25 mg/kg body weight), has been used as an addiction-interrupting agent. Its effects persist for up to 72 h. Ex vivo results showed that ibogaine ... induced cellular energy consumption and restitution, followed by increased reactive oxygen species production and antioxidant activity. Therefore, the aim of this work was to explore the effect of a single oral dose of ibogaine (1 or 20 mg/kg body weight) on antioxidative defenses in rat liver and erythrocytes. Six and 24 h after ibogaine administration, histological examination showed glycogenolytic activity in hepatocytes, which was highest after 24 h in animals that received 20 mg/kg ibogaine. There were no changes in the activities of superoxide dismutases, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase in the liver and erythrocytes after ibogaine treatment, regardless of the dose. Hepatic xanthine oxidase activity was elevated in rats that received 20 mg/kg compared to the controls (p<0.01), suggesting faster adenosine turnover. TBARS concentration was elevated in the group treated with 1 mg/kg after 24 h compared to the controls (p<0.01), suggesting mild oxidative stress. Our results show that ibogaine treatment influenced hepatic redox homeostasis, but not sufficiently to remodel antioxidant enzyme activities at 6 and 24 h post-ibogaine application. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 173014: Molecular mechanisms of redox signaling in homeostasis, adaptation and pathology]Source: Archives of biological sciences : [official journal of the Serbian Biological Society]. - ISSN 0354-4664 (Vol. 71, iss. 1, 2019, str. 133-144)Type of material - article, component part ; adult, seriousPublish date - 2019Language - englishCOBISS.SI-ID - 34217689
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source: Archives of biological sciences : [official journal of the Serbian Biological Society]. - ISSN 0354-4664 (Vol. 71, iss. 1, 2019, str. 133-144)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Vidonja-Uzelac, Teodora | ![]() |
Tatalović, Nikola | ![]() |
Mijović, Milica | ![]() |
Koželj, Gordana | 01846 |
Nikolić-Kokić, Aleksandra | ![]() |
Oreščanin-Dušić, Zorana | ![]() |
Bresjanac, Mara | 10428 |
Blagojević, Duško | ![]() |
Source: Personal bibliographies
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