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ADORA2A polymorphisms influence methotrexate adverse events in rheumatoid arthritisKobold, Nadja ...Background: Methotrexate is the most frequently administered first-line treatment for rheumatoid arthritis (RA). The disease-modifying effects of methotrexate are mainly associated with enhanced ... release of free adenosine. The downstream anti-inflammatory effects of adenosine are mediated via its binding to adenosine receptor 2A (ADORA2A) and 3 (ADORA3). Many clinically important single nucleotide polymorphisms (SNPs) were reported in ADORA2A and ADORA3 genes. Objectives: To investigate whether tagging ADORA2A and ADORA3 polymorphisms influences methotrexate treatment in RA. Methods: In total, 212 RA patients treated with methotrexate were genotyped for tagging ADORA2A (rs2298383, rs8141793, rs2236624, rs5751876, rs35320474, and rs17004921) and ADORA3 SNPs (rs2298191, rs1544223, rs78594984, rs35511654, rs2229155, rs3393, and rs3394). Results: RA patients who carried ADORA3 rs35511654 G allele showed a tendency toward better response to methotrexate treatment (P = 0.054). Carriers of ADORA2A polymorphic allele rs2298383 (P = 0.011), rs2236624 (P = 0.027), rs5751876 (P = 0.018), and rs35320474 (P = 0.026) were less likely to experience methotrexate induced adverse events. All associations remained significant after adjustment for clinical factors. The effects of these polymorphisms were also significant in haplotype analyses. Conclusions: Polymorphisms in the ADORA2A gene may influence methotrexate treatment response and may be considered as a potential biomarker for methotrexate treatment in rheumatoid arthritis.Source: The Israel Medical Association Journal : IMAJ. - ISSN 1565-1088 (Vol. 21, May 2019, str. 333-338)Type of material - article, component partPublish date - 2019Language - englishCOBISS.SI-ID - 34393561
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source: The Israel Medical Association Journal : IMAJ. - ISSN 1565-1088 (Vol. 21, May 2019, str. 333-338)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kobold, Nadja | ![]() |
Jenko Bizjan, Barbara, 1988- | 35356 |
Tomšič, Matija, 1959- | 13601 |
Dolžan, Vita | 11711 |
Praprotnik, Sonja | 13602 |
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