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Chemical synthesis and immunological characteristics of new acyclic MDP-derivative, LK-404
Sollner Dolenc, Marija ...
The chemical synthesis and some immunological characteristics of a new acyclic apyrogenic and low toxic desmuramyl dipeptide derivate-N-(7-oxododecanoyl)-L-alanyl-D-isloglutamine (LK-404) are ...described in this paper. The influence of LK-404 on B lymphocytes differentiation measured with Jerne's haemolytic plaque assay was compared with those of romurtide (Nopia R,(MDP-Lys(L18) at the doses 2.5 and 25 nmol/mouse.LK-404 shows similar effects as Nopia, especially at lower dose (2.5 nmol/mouse). The present data suggest that the humoral response can be augmented by LK-404.This compound also shows an immunorestorative activity which is expressed in an increased survival rate.
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