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Neuroprotective role of ▫$gama$▫-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin XPišlar, Anja ...Gama-Enolase is a neurotrophic-like factor promoting growth, differentiation, survival and regeneration of neurons. Its neurotrophic activity is regulated by cysteine protease cathepsin X which ... cleaves the C-terminal end of the molecule. We have investigated the expression and co-localization of Gama-enolase and cathepsin X in brains of Tg2576 mice overexpressing amyloid precursor protein. In situ hybridization of gama-enolase and cathepsin X revealed that mRNAs for both enzymes were expressed abundantly around amyloid plaques. Immunostaining demonstrated that the C-terminally cleaved form of gama-enolase was present in the immediate plaque vicinity, whereas the intact form, exhibiting neurotrophic activity, was observed in microglia cells in close proximity to senile plaque. The upregulation of gama-enolase in microglial cells in response to amyloid-ß peptide (Aß) was confirmed in mouse microglial cell line EOC 13.31 and primary microglia and medium enriched with gama-enolase proved to be neuroprotective against Aß toxicity, however, the effect was reversed by cathepsin X proteolytic activity. These results demonstrate an upregulation of gama-enolase in microglia cells surrounding amyloid plaques in Tg2576 transgenic mice and demonstrate its neuroprotective role in amyloid-ß-related neurodegeneration.Source: Aging cell. - ISSN 1474-9718 (Vol. 12, iss. 4, 2013, str. 604-614)Type of material - article, component partPublish date - 2013Language - englishCOBISS.SI-ID - 3441265
Author
Pišlar, Anja |
Glavan, Gordana |
Obermajer, Nataša |
Živin, Marko, 1958- |
Schliebs, Reinhard |
Kos, Janko, 1959-
Topics
gama enolaze |
katepsin X |
Alzheimerjeva bolezen |
amiloid ß
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Pišlar, Anja | 32035 |
Glavan, Gordana | 18324 |
Obermajer, Nataša | 25494 |
Živin, Marko, 1958- | 08289 |
Schliebs, Reinhard | |
Kos, Janko, 1959- | 04648 |
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