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Involvement of sulfatase 1 (SULF1) in colorectal cancer [Elektronski vir]Urh, Kristian ...Colorectal cancer (CRC) is one of the most common cancers worldwide. Molecular pathways involved in CRC development include stepwise accumulation of mutations, epigenetic changes, and changes in gene ... expression, leading to uncontrolled cell division and an invasive phenotype. However, not all cases possess these changes suggesting that there should be undiscovered mechanisms for CRC development. We therefore investigated SULF1, previously identified as a CRC candidate gene using bioinformatics analysis. We included 65 biopsy samples from patients with adenoma, malignant adenoma, and CRC with and without nodal metastases. We examined expression of SULF1 using quantitative real-time polymerase chain reaction. Its expression progressively increased from adenoma, where it was down-regulated, to invasive CRC, where it was up-regulated. Our findings indicate an involvement of SULF1 in CRC carcinogenesis and progression.Source: Proceedings [Elektronski vir] (Str. 19-24)Type of material - conference contributionPublish date - 2019Language - englishCOBISS.SI-ID - 34521561
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Urh, Kristian | 51961 |
Žlajpah, Margareta | 51028 |
Boštjančič, Emanuela, 1979 | 25441 |
Zidar, Nina, 1960- | 12955 |
Source: Personal bibliographies
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