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Aripiprazole reduces liver cell division [Elektronski vir]Pirc Marolt, Tinkara ...Effects of aripiprazole on dopamine regulation are being tested as a treatment for patients with a dual diagnosis of schizophrenia and addictions, often cocaine dependence. Aripiprazole has one of ... the fewest side-effects among the second-generation antipsychotics. Nevertheless, severe aripiprazole hepatotoxicity was reported in persons with a history of cocaine and alcohol abuse. Here we report that therapeutically relevant aripiprazole concentrations, equal to laboratory alert levels in patients' serum, reduce the rate of hepatocytes' division. This could be an underlying mechanism of severe liver injury development in the patients with a history of alcohol and cocaine abuse, the two hepatotoxic agents that require increased ability of liver self-regeneration. Monitoring liver functions is, therefore, important in the cases when aripiprazole is co-prescribed or used with drugs with potential hepatotoxic effects.Source: PloS one [Elektronski vir]. - ISSN 1932-6203 (Vol. 15, no. 10, Oct. 2020, str. 1-15)Type of material - e-article ; adult, seriousPublish date - 2020Language - englishCOBISS.SI-ID - 34546691
Author
Pirc Marolt, Tinkara |
Kramar, Barbara, 1991- |
Bulc Rozman, Klara |
Šuput, Dušan |
Milisav, Irina
Topics
aripiprazol |
jetra |
poškodbe |
aripiprazole |
liver |
injury
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Pirc Marolt, Tinkara | 37609 |
Kramar, Barbara, 1991- | 52520 |
Bulc Rozman, Klara | 27580 |
Šuput, Dušan | 07002 |
Milisav, Irina | 18825 |
Source: Personal bibliographies
and: SICRIS
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