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Human telomerase gene amplification and high-risk human papillomavirus infection in women with cervical intra-epithelial neoplasiaTakač, Iztok ...This study was designed to investigate whether a correlation exists between amplification of the human telomerase gene (human telomerase RNA component [TERC]) and high-risk human papillomavirus ... (HR-HPV) infection in 101 women with cervical intra-epithelial neoplasia (CIN). Eight patients (7.9%) had CIN 1, 24 (23.8%) had CIN 2 and 69 (68.3%) had CIN 3. TERC was amplified in 31.7% of all CIN patients. The difference in frequency of TERC amplification between patients with low-grade CIN (CIN 1) and those with high-grade CIN (CIN 2 and CIN 3) was not significant. HR-HPV infection was detected in 88.1% of all CIN cases and was significantly more frequent in patients with CIN 2 and CIN 3 than in patients with CIN 1. There was no significant difference in the frequency of HR-HPV infection between groups of patients with and without TERC amplification. In conclusion, this study found no correlation between TERC amplification and HR-HPV infection in patients with CIN.Source: Journal of international medical research. - ISSN 0300-0605 (Vol. 37, no. 5, 2009, str. 1588-1595)Type of material - article, component part ; adult, seriousPublish date - 2009Language - englishCOBISS.SI-ID - 3455295
Author
Takač, Iztok |
Arko, Darja |
Kodrič, Tatjana, 1946- |
Poljak, Mario, 1965- |
Zagorac, Andreja |
Erjavec Škerget, Alenka, 1974- |
Kokalj-Vokač, Nadja
Topics
Cervical Intraepithelial Neoplasia |
Cervikalna intraepitelijska neoplazija |
Papillomavirus Infections |
Papilomavirus, okužbe |
Telomerase |
Telomeraza |
Gene Amplification |
Gen, amplifikacija
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Takač, Iztok | 01324 |
Arko, Darja | 14114 |
Kodrič, Tatjana, 1946- | 05332 |
Poljak, Mario, 1965- | 11622 |
Zagorac, Andreja | 15747 |
Erjavec Škerget, Alenka, 1974- | 20135 |
Kokalj-Vokač, Nadja | 13343 |
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