-
Synergistic effect of cisplatin chemotherapy combined with fractionated radiotherapy regimen in HPV-positive and HPV-negative experimental pharyngeal squamous cell carcinoma [Elektronski vir]Kranjc Brezar, Simona ...in a favorable prognosis for HPV-positive patients treated with radiation alone or with concurrent platinum-based chemotherapy. The degree of radiosensitivity in fractionated regimens has not yet ... been fully explored; therefore, in this study, the radiosensitivity of HPV-negative tumors (FaDu) was compared to that of HPV-positive tumors (2A3) subjected to concurrent cisplatin chemotherapy and fractionated versus isoeffective single-dose tumor irradiation in immunodeficient mice. HPV-positive tumors were approximately 5 times more radiosensitive than HPV-negative tumors, irrespective of the irradiation regimen. In both tumor models, concurrent cisplatin chemotherapy and the fractionated regimen induced significant tumor radiosensitization, with a 3- to 4-fold increase in the tumor growth delay compared to that of single-dose irradiation. Furthermore, the degree of radiosensitization induced by cisplatin chemotherapy concurrent with the fractionated irradiation regimen was much higher in HPV-positive tumors, where a synergistic antitumor effect was observed. Specifically, after combined therapy, a 26% higher survival rate was observed in mice with HPV-positive tumors than in mice with HPV-negative tumors. These data suggest that HPV-positive tumors are more radiosensitive to fractionated regimen than to single-dose irradiation with concurrent cisplatin chemotherapy acting synergistically to irradiation.Source: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 10, 2020, str. [1-9])Type of material - e-articlePublish date - 2020Language - englishCOBISS.SI-ID - 3455611
Author
Kranjc Brezar, Simona |
Prevc, Ajda |
Nikšić Žakelj, Martina |
Brožič, Andreja |
Čemažar, Maja |
Strojan, Primož |
Serša, Gregor
Topics
cisplatin |
kemoterapija |
ploščatocelični rak |
rak glave in vratu |
eksperimentalna onkologija |
cisplatin |
chemotherapy |
squamous cell carcinoma |
oropharyngeal cancer |
experimental oncology
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Kranjc Brezar, Simona | 19058 |
Prevc, Ajda | 37415 |
Nikšić Žakelj, Martina | 38225 |
Brožič, Andreja | 35354 |
Čemažar, Maja | 14575 |
Strojan, Primož | 14576 |
Serša, Gregor | 08800 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.