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Cannabinoids and hormone receptor - positive breast cancer treatment [Elektronski vir]Dobovišek, Luka ...Breast cancer (BC) is the most common cancer in women worldwide. Approximately 70- 80% of BCs express estrogen receptors (ER), which predict the response to endocrine therapy (ET), and are therefore ... hormone receptor-positive (HR+). Endogenous cannabinoids together with cannabinoid receptor 1 and 2 (CB1, CB2) constitute the basis of the endocannabinoid system. Interactions of cannabinoids with hypothalamic-pituitary-gonadal axis hormones are well documented, and two studies found a positive correlation between peak plasma endogenous cannabinoid anandamide with peak plasma 17[beta]-estradiol, luteinizing hormone and folliclestimulating hormone levels at ovulation in healthy premenopausal women. Do cannabinoids have an effect on HR+ BC? In this paper we review known and possible interactions between cannabinoids and specific HR+ BC treatments. In preclinical studies, CB1 and CB2 agonists (i.e., anandamide, THC) have been shown to inhibit the proliferation of ER positive BC cell lines. There is less evidence for antitumor cannabinoid action in HR+ BC in animal models and there are no clinical trials exploring the effects of cannabinoids on HR+ BC treatment outcomes. Two studies have shown that tamoxifen and several other selective estrogen receptor modulators (SERM) can act as inverse agonists on CB1 and CB2, an interaction with possible clinical consequences. In addition, cannabinoid action could interact with other commonly used endocrine and targeted therapies used in the treatment of HR+ BC.Source: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 12, iss. 3, 2020, str. 1-12)Type of material - e-articlePublish date - 2020Language - englishCOBISS.SI-ID - 34716889
Author
Dobovišek, Luka |
Krstanović, Fran |
Borštnar, Simona, 1967- |
Debeljak, Nataša
Topics
hormonski receptor |
rak dojke |
kanabinoidi |
hormone receptor |
breast cancer |
cannabinoids
Author | Dobovišek, Luka ... |
Title | Cannabinoids and hormone receptor - positive breast cancer treatment [Elektronski vir] |
Publication date | 2020-02-25 |
COBISS.SI-ID | 34716889 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrst raka | P3-0321-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Funkcijska genomika in biotehnologija za zdravje | P1-0390-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://www.mdpi.com/2072-6694/12/3/525 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=133624 |
Costs of publication
Cost type | Total cost | Payments |
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APC – Article Processing Charge | 2063.25 € |
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Dobovišek, Luka | 52511 |
Krstanović, Fran | |
Borštnar, Simona, 1967- | 16303 |
Debeljak, Nataša | 18622 |
Source: Personal bibliographies
and: SICRIS
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