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Cinnamic Acid derivatives induce cell cycle arrest in carcinoma cell linesSova, Matej, 1979- ...Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of ... representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of theplant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC50s between 42 and 166 ŽM) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol oramine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.Source: Medicinal chemistry. - ISSN 1573-4064 (Vol. 9, iss. 5, 2013, str. 633-641)Type of material - article, component partPublish date - 2013Language - englishCOBISS.SI-ID - 3492977
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sova, Matej, 1979- | 25490 |
Žižak, Željko | |
Stanković, Jelena | |
Prijatelj, Matevž | 29602 |
Turk, Samo, farmacevt | 29773 |
Juranić, Zorica | |
Mlinarič-Raščan, Irena | 12443 |
Gobec, Stanislav, 1970- | 15284 |
Source: Personal bibliographies
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