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  • Synthesis of conformationally constrained $ʼgammaʼ$-D-glutamyl-meso-diaminopimelic acid derivatives as ligands of nucleotide-binding oligomerization domain protein 1 (Nod1)
    Jakopin, Žiga ...
    Nod1, an important member of the pattern recognition receptor family, remains a virtually unexploited target. Harnessing its innate immune stimulatory properties still remains an unfulfilled goal of ... medicinal chemistry. Nucleotide-binding oligomerization domain protein 1 (Nod1) agonists have been shown to boost the inflammatory responses against pathogenic microbes and could thus constitute a new class of broad spectrum antimicrobial agents. To gain additional insight into the structure/activity relationships of Nod1 agonistic compounds, a series of novel, conformationally constrained Ž-D-glutamyl-meso-diaminopimelic acid (iE-DAP) analogs have been designed and synthesized. Ramos-Blue cells expressing Nod1 were used to screen and validateour compounds for their Nod1-agonist activity. Their immunomodulatory properties were subsequently determined in vitro, by evaluating their capacityto induce proinflammatory cytokine and chemokine production from humanperipheral blood mononuclear cells (PBMC), by themselves and in synergy with lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) ligand. The synthesized iE-DAP analogs were shown to possess immuno-enhancing properties as a result of their potent and specific Nod1-agonistic effect. The activity of the compound exhibiting the greatest capacity to induce pro-inflammatory cytokine release from PBMC surpassed that of lauroyl-Ž-D-glutamyl-meso-diaminopimelic acid (C12-iE-DAP).
    Source: European journal of medicinal chemistry. - ISSN 0223-5234 (Vol. 69, Nov. 2013, str. 232-243)
    Type of material - article, component part
    Publish date - 2013
    Language - english
    COBISS.SI-ID - 3506033

    Link(s):

    http://www.sciencedirect.com/science/article/pii/S022352341300528X#
    DOI

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