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MurD enzymes: some recent developmentsŠink, Roman ...The synthesis of the peptide stem of bacterial peptidoglycan involves four enzymes, the Mur ligases (MurC, D, E and F). Among them, MurD is responsible for the ATP-dependent addition of D-glutamic ... acid to UDP-MurNAc-L-Ala, a reaction which involves acyl-phosphate and tetrahedral intermediates. As most enzymes of peptidoglycan biosynthesis, MurD constitutes an attractive target for the design and synthesis of new antibacterial agents. Escherichia coli MurD has been the first Mur ligase for which the tridimensional structure was solved. Thereafter, several co-crystal structures with different ligands or inhibitors were released. In the present review, we will deal with work performed on substrate specificity, reaction mechanism and 3D structure of E. coli MurD. Then, a part of the review will be devoted to recent work on MurD orthologs from species other than E. coli, and to cellular organization of Murligases and in vivo regulation of the MurD activity. Finally, we will review the different classes of MurD inhibitors that have been designed and assayed to date with the hope of obtaining new antibacterial compounds.Source: Biomolecular concepts. - ISSN 1868-5021 (Vol. 4, iss. 6, 2013, str. 539-556)Type of material - article, component partPublish date - 2013Language - englishCOBISS.SI-ID - 3520881
Author
Šink, Roman |
Barreteau, Hélène |
Patin, Delphine |
Mengin-Lecreulx, Dominique |
Gobec, Stanislav, 1970- |
Blanot, Didier
Topics
MurD encim |
Mur ligaze |
inhibitorji |
peptidoglikan
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Šink, Roman | 28862 |
Barreteau, Hélène | |
Patin, Delphine | |
Mengin-Lecreulx, Dominique | |
Gobec, Stanislav, 1970- | 15284 |
Blanot, Didier |
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