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Inhibitors of the peptidoglycan biosynthesis enzymes MurA-FHrast, Martina ...The widespread emergence of resistant bacterial strains is becoming a serious threat to public health. This thus signifies the need for the development of new antibacterial agents with novel ... mechanisms of action. Continuous efforts in the design of novel antibacterials remain one of the biggest challenges in drug development. In this respect, the Mur enzymes, MurA-F, that are involved in the formation of UDP-N-acetylmuramyl-pentapeptide can be genuinely considered as promising antibacterial targets. This review provides an in-depth insight into the recent developments in the field of inhibitors of the MurA-F enzymes. Special attention is also given to compounds that act as multiple inhibitors of two, three or more of the Mur enzymes. Moreover, the reasons for the lack of preclinically successful inhibitors and the challenges to overcome these hurdles in the next years are also debated.Source: Bioorganic chemistry. - ISSN 0045-2068 (Vol. 55, 2014, str. 2-15)Type of material - article, component part ; adult, seriousPublish date - 2014Language - englishCOBISS.SI-ID - 3629169
Author
Hrast, Martina |
Sosič, Izidor |
Šink, Roman |
Gobec, Stanislav, 1970-
Topics
antibiotiki |
peptidoglikan |
Mur encimi |
encimski inhibitorji |
raziskava zdravil
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hrast, Martina | 32036 |
Sosič, Izidor | 30816 |
Šink, Roman | 28862 |
Gobec, Stanislav, 1970- | 15284 |
Source: Personal bibliographies
and: SICRIS
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