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Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidinHodnik, Žiga, farmacevt ...Herein, we describe indole-based analogues of oroidin as a novel class of 2-aminoimidazolebased inhibitors of methicillin-resistant S. aureus biofilm formation and, to the best of our knowledge, the ... first reported 2-aminoimidazole-based inhibitors of S. mutans biofilm formation. This study highlighted the indole moiety as a dibromopyrrole mimetic for obtaining inhibitors of S. aureus and S. mutans biofilm formation. The most potent compound in the series, 5- (trifluoromethoxy)indole-based analogue 4b (MBIC50 = 20 [micro]M), emerged as a promising hit for further optimisation of novel inhibitors of S. aureus and S. mutans biofilms.Source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 24, iss. 11, 2014, str. 2530-2534)Type of material - article, component part ; adult, seriousPublish date - 2014Language - englishCOBISS.SI-ID - 3630449
Author
Hodnik, Žiga, farmacevt |
Łoś, Joanna M. |
Žula, Aleš |
Zidar, Nace |
Jakopin, Žiga |
Łoś, Marcin |
Sollner Dolenc, Marija |
Ilaš, Janez |
Węgrzyn, Grzegorz |
Peterlin-Mašič, Lucija |
Kikelj, Danijel
Topics
biofilm |
indole |
inhibition |
marine |
oroidin |
anti-biofilm activities
source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 24, iss. 11, 2014, str. 2530-2534)
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hodnik, Žiga, farmacevt | 33052 |
Łoś, Joanna M. | |
Žula, Aleš | 33054 |
Zidar, Nace | 28905 |
Jakopin, Žiga | 26496 |
Łoś, Marcin | |
Sollner Dolenc, Marija | 08519 |
Ilaš, Janez | 24400 |
Węgrzyn, Grzegorz | |
Peterlin-Mašič, Lucija | 19317 |
Kikelj, Danijel | 01463 |
Source: Personal bibliographies
and: SICRIS
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