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DNA polymerase ▫$\beta$▫ catalytic efficiency mirrors the Asn279-dCTP H-bonding strengthMartínek, Václav ...Ternary complexes of wild type or mutant form of human DNA polymerase ß (pol ß) bound to DNA and dCTP substrates were studied by molecular dynamics (MD) simulations. The occurrences of contact ... configurations (CC) of structurally important atom pairs were sampled along the MD trajectories, and converted into free-energy differences, ŽGCC. ŽGCC values were correlated with the experimental binding and catalytic free energies for the wild type pol ß and its Arg183Ala, Tyr271Ala, Asp276Val, Lys280Gly, Arg283Ala, and Glu295Ala mutants. The correlation coefficients show that the strength of the H-bond between dCTP and Asn279 is a strong predictor of the mutation-induced changes in the catalytic efficiency of pol ß. This finding is consistent with the viewthat enzyme preorganization plays a major role in controlling DNA polymerase specific activity.Source: FEBS letters. - ISSN 0014-5793 (Vol. 581, no. 4, 2007, str. 775-780)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 3658010
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Martínek, Václav | ![]() |
Bren, Urban | 25434 |
Goodman, Myron F. | ![]() |
Warshel, Arieh | ![]() |
Florián, Jan | ![]() |
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