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Clinical routine utility of basophil activation testing for diagnosis of Hymenoptera-allergic patients with emphasis on individuals with negative venom-specific IgE antibodiesKorošec, Peter, 1970- ...Background: Previous reports suggest the usefulness of basophil activation testing (BAT) in Hymenoptera-allergic patients with negative venom-specific IgE antibodies. We sought to evaluate the ... diagnostic utility of this testing in a routine clinical laboratory setting. Materials and Methods: Twenty-one patients with anaphylactic reactions to Hymenoptera sting (median grade III) and negative venom-specific IgE were routinely and prospectively tested with BAT. Results: We were able to diagnose 81% (17 of 21) of patients with BAT and 57% (12 of 21) with intradermal skin testing. Three wasp venom-allergic patients showed IgE positivity to rVes v 5. Four patients (19%) were negative for all tests. In the case of double-positive BAT, the culprit insect correlated with the venom that induced a significantly higher basophil response. Conclusions: BAT allows the identification of severe Hymenoptera-allergic patients with negative specific IgE and skin tests. The routine use of this cellular test should facilitate prescription of venom immunotherapy in complex cases with inconclusive diagnostic results.Source: International archives of allergy and immunology. - ISSN 1018-2438 (Vol. 161, 2013, str. 363-368)Type of material - article, component partPublish date - 2013Language - englishCOBISS.SI-ID - 36694789
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source: International archives of allergy and immunology. - ISSN 1018-2438 (Vol. 161, 2013, str. 363-368)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Korošec, Peter, 1970- | 22807 |
Šilar, Mira | 25331 |
Eržen, Renato | 25171 |
Čelesnik Smodiš, Nina | 32076 |
Bajrović, Nisera | 25336 |
Zidarn, Mihaela | 25317 |
Košnik, Mitja | 10921 |
Source: Personal bibliographies
and: SICRIS
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