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  • Hymenoptera-venom basophil activation test should be routinely performed in patients with positive history and negative skin and specific IgE results [Elektronski vir]
    Šilar, Mira ...
    Background: Significant number of patients with a clear history of insect allergies have a negative skin and sIgE tests. The aim of our study was to show the applicability of the CD63 basophil ... activation test in detecting hypersensitivity to Hymenoptera venom. Method: Twenty-one patients with anaphylactic reactions to Hymenoptera sting (median grade III) and negative venom-specific IgE were routinely and prospectively tested with BAT. Results: We diagnosed 81% (17 of 21) of patients with basophil activation test (BAT) and 57% (12 of 21) with intradermal skin testing. Three wasp venom-allergic patients showed IgE positivity to rVes v 5. Four patients (19%) were negative for all tests. In the case of double-positive BAT, the culprit insect correlated with the venom that induced a significantly higher basophil response. Conclusion: BAT allows the identification of severe Hymenoptera venom allergic patients with negative skin and sIgE tests. The routine use of this cellular test should facilitate prescription of venom immunotherapy in complex cases with inconclusive diagnostic results.
    Source: European Academy of Allergy and Clinical Immunology & World Allergy Organization World Allergy & Asthma Congress 2013, 22-26 June, Milan, Italy [Elektronski vir] (Str. [1])
    Type of material - conference contribution ; adult, serious
    Publish date - 2013
    Language - english
    COBISS.SI-ID - 36918533

    Link(s):

    http://www.sessionplan.com/EAACI-WAO2013/
    https://onlinelibrary.wiley.com/toc/13989995/2013/68/s97

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