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  • Down-regulation of Fc[epsilon]RI-mediated basophil response during short-term VIT determined non-specific allergen desensitization [Elektronski vir]
    Čelesnik Smodiš, Nina ...
    Background: We recently showed a desensitisation of Fc[epsilon]RI-mediated basophil response after short-term VIT. Our aim was to evaluate if the observed basophil desensitisation is allergen ... specific. Method: In 10 Hymenoptera venom double sensitised and 2 mono sensitised subjects basophil threshold sensitivity (CD-sens) to anti-Fc[epsilon]RI, honeybee and Vespula venom was assessed at the beginning and just before the first maintenance dose (MD) of single ultra-rush VIT. Genuine double sensitisation to both venoms was confirmed in 7 subjects with recombinant Api m 1 and Ves v 5 and/or Ves v 1. Results: We demonstrated a marked reduction of CD-sens to anti-Fc[epsilon]RI and VIT-specific Hymenoptera venom before the first MD in all included subjects. Furthermore a significant and comparable decrease was evident both in VIT and non-VIT Hymenoptera venom before the first MD of single ultra-rush VIT in 9 out of 10 double sensitised subjects. Most evident decreases in CD63 basophil response were achieved at low submaximal concentrations of allergen stimulation. Conclusion: Short-term VIT induced basophil desensitisation of VIT-specific as well as VIT-non-specific allergen. In genuinely double sensitised subjects to both venoms the decrease in basophil response was evident both in VIT and non-VIT Hymenoptera venom. As opposed to long-term VIT which induces allergen-specific basophil changes, the mechanisms of short-term VIT seem to be allergen non-specific.
    Source: European Academy of Allergy and Clinical Immunology & World Allergy Organization World Allergy & Asthma Congress 2013, 22-26 June, Milan, Italy [Elektronski vir] (Str. [1])
    Type of material - conference contribution ; adult, serious
    Publish date - 2013
    Language - english
    COBISS.SI-ID - 36918789

    Link(s):

    http://www.sessionplan.com/EAACI-WAO2013/
    https://onlinelibrary.wiley.com/toc/13989995/2013/68/s97

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