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  • Targeting tumor cells and stimulus-induced delivery of drug with mesoporous silica nanoparticles-based system [Elektronski vir]
    Nadrah, Peter ...
    Drug delivery systems based on mesoporous silica nanoparticles (MSNs) have received much attention recently. Biocompatibility, chemical stability, ease of functionalization and porosity have ... attributed to the popularity of MSNs. Functional groups on surface allow stimulus-induced release of the cargo with zero premature release. In this regard glutathione is an important stimulus since the difference between intracellular and extracellular concentration allow drug release only inside cells. Moreover, the ability to deliver a significant amount of drug in a specific environment is an important prerequisite to prevent severe side effects. Selective targeting of delivery systems towards cancer cells is possible via their overexpressed folate receptors. Herein we present a novel type of functionalized MSNs able to incorporate targeting ability towards specific cells and release the drug upon endogenous stimulus with activation of the nanovalve. We synthesized fluorescent dye loaded MSNs (100 nm). Next, dendrimers were attached to the mesopore openings to act as a stopper and prevent leakage of the dye. The outer surface of particles was decorated with folic acid moieties providing affinity to folate receptors. Upon the addition of reducing agent the dendrimers detached and released the dye. In conclusion we have synthesized target selective MSNs with the ability to safely transport drug avoiding its premature release. Drug release is enabled only upon biological stimulus.
    Source: Functional Biomaterials [Elektronski vir]
    Type of material - conference contribution
    Publish date - 2012
    Language - english
    COBISS.SI-ID - 36964101

    Link(s):

    http://www.emrs-strasbourg.com/index.php?option=com_abstract&task=view&id=174&year=2012&Itemid=&id_season=6&PHPSESSID=4a1e1f1d31b21a6fd9719daeacb1dc20#

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