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  • The current stage of cathepsin B inhibitors as potential anticancer agents [Elektronski vir]
    Kos, Janko, 1959- ; Mitrović, Ana ; Mirković, Bojana
    Cathepsin B is a lysosomal cysteine peptidase, with an important role in the development and progression of cancer. It is involved in the degradation of extracellular matrix proteins, a process ... promoting invasion and metastasis of tumor cells and tumor angiogenesis. Cathepsin B is unique among cathepsins in possessing both carboxypeptidase and endopeptidase activities. While the former is associated with its physiological role, the latter is involved in pathological degradation of the extracellular matrix. Its activities are regulated by different means, the most important being its endogenous inhibitors, the cystatins. In cancer this peptidase/inhibitor balance is altered, leading to harmful cathepsin B activity. The latter can be prevented by exogenous inhibitors. They differ in modes of inhibition, size, structure, binding affinity, selectivity, toxicity and bioavailability. In this article, we review the properties and function of endogenous and exogenous cathepsin B inhibitors and indicate their application as possible anticancer agents.
    Source: Future medicinal chemistry. - ISSN 1756-8919 (Vol. 6, no. 11, 2014, Str. 1355-1371)
    Type of material - e-article
    Publish date - 2014
    Language - english
    COBISS.SI-ID - 3730545

    Link(s):

    http://www.future-science.com/doi/abs/10.4155/fmc.14.73
    DOI

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