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Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer [Elektronski vir] : final analysis of the GioTag studyHochmair, Maximilian J ...Aim: Final overall survival (OS) and time on treatment analysis of patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC) who received sequential afatinib and osimertinib. Patients & ... methods: Patients (n = 203) had T790M-positive disease following first-line afatinib and started osimertinib treatment >/=10 months before data entry. Primary outcome was time on treatment; OS analysis was exploratory. Results: Median time on treatment with afatinib and osimertinib was 27.7 months (90% CI: 26.7-29.9). Median OS was 37.6 months (90% CI: 35.5-41.3); median OS was 41.6 and 44.8 months in Del19-positive patients and Asian patients, respectively. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib was associated with encouraging outcomes in patients with EGFR mutation-positive NSCLC, especially in Del19-positive patients and Asian patients.Source: Future oncology. - ISSN 1744-8301 (Vol. 16, iss. 34, Dec. 2020, str. 2799-2808)Type of material - e-article ; adult, seriousPublish date - 2020Language - englishCOBISS.SI-ID - 37424899
Author
Hochmair, Maximilian J |
Morabito, Alessandro |
Hao, Desiree |
Yang, Cheng-Ta |
Soo, Ross A |
Yang, James C-H |
Gucalp, Rasim |
Halmos, Balazs |
Märten, Angela |
Čufer, Tanja, 1955-
Topics
Carcinoma, non-small cell lung |
Therapy |
Drug therapy |
Afatinib |
Nedrobnocelični karcinom pljuč |
Terapija |
Terapija z zdravili |
Afatinib |
osimertinib |
raziskava GioTag |
osimertinib |
GioTag study
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hochmair, Maximilian J | |
Morabito, Alessandro | |
Hao, Desiree | |
Yang, Cheng-Ta | |
Soo, Ross A | |
Yang, James C-H | |
Gucalp, Rasim | |
Halmos, Balazs | |
Märten, Angela | |
Čufer, Tanja, 1955- | 12179 |
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