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  • Association of ITPA genotype with event-free survival and relapse rates in children with acute lymphoblastic leukemia undergoing maintenance therapy [Elektronski vir]
    Šmid, Alenka, farmacevtka ...
    Although the treatment of acute lymphoblastic leukemia (ALL) has improved significantly over recent decades, failure due to treatment-related toxicitiesand relapse of the disease still occur in about ... 20% of patients. This retrospective study included 308 pediatric ALL patients undergoing maintenance therapy and investigated the effects of genetic variants of enzymes involved in the 6-mercaptopurine (6-MP) metabolism and folate pathway on survival and relapse rates. The presence of at least one of the non-functional ITPA alleles (94C.A and/or IVS2+21A.C variant) was associated with longer event-free survival compared to patients with the wild-type ITPA genotype (p = 0.033). Furthermore, patients carrying at least one non-functional ITPA allele were shown to be at a lower risk of suffering early(p = 0.003) and/or bone marrow relapse (p = 0.017). In conclusion, the ITPA genotype may serve as a genetic marker for the improvement of risk stratification and therapy individualization for patients with ALL.
    Source: PloS one [Elektronski vir]. - ISSN 1932-6203 (Vol. 9, iss. 10, Oct. 2014, str. 1-10)
    Type of material - e-article ; adult, serious
    Publish date - 2014
    Language - english
    COBISS.SI-ID - 3742577

    Link(s):

    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0109551
    DOI

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