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The clinical relevance of oliguria in the critically ill patient [Elektronski vir] : analysis of a large observational databaseVincent, Jean Louis ...Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of ... acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient-oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged-oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent-oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19%1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97%1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.Source: Critical care [Elektronski vir]. - ISSN 1466-609X (Vol. 24, 2020, str. 1-14)Type of material - e-article ; adult, seriousPublish date - 2020Language - englishCOBISS.SI-ID - 37575171
Author
Vincent, Jean Louis |
Ferguson, Andrew |
Pickkers, Peter |
Jakob, Stephan M. |
Jaschinski, Ulrich |
Almekhlafi, Ghaleb A. |
Leone, Marc |
Mokhtari, Majid |
Fontes, Luis E. |
Bauer, Philippe R. |
Sakr, Yasser
Other authors
Voga, Gorazd |
Rupnik, Erik, 1962- |
Kosec, Lučka |
Kerin-Povšič, Milena |
Osojnik, Irena |
Tomič, Viktorija |
Sinkovič, Andreja
Topics
Critical care |
Critical illness |
Urine |
Oliguria |
Kidney |
Renal insufficiency |
Kidney diseases |
Kidney failure, acute |
Mortality |
Oskrba kritično bolnih |
Kritično stanje |
Urin |
Oligurija |
Ledvica |
Renalna insuficienca |
Bolezni ledvic |
Akutna ledvična odpoved |
Umrljivost |
izločanje urina |
nadomestno zdravljenje ledvične odpovedi |
urine output |
renal replacement therapy
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Database name | Field | Year |
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Vincent, Jean Louis | ![]() |
Ferguson, Andrew | ![]() |
Pickkers, Peter | ![]() |
Jakob, Stephan M. | ![]() |
Jaschinski, Ulrich | ![]() |
Almekhlafi, Ghaleb A. | ![]() |
Leone, Marc | ![]() |
Mokhtari, Majid | ![]() |
Fontes, Luis E. | ![]() |
Bauer, Philippe R. | ![]() |
Sakr, Yasser | ![]() |
Voga, Gorazd | 14132 |
Rupnik, Erik, 1962- | 50373 |
Kosec, Lučka | ![]() |
Kerin-Povšič, Milena | 21759 |
Osojnik, Irena | ![]() |
Tomič, Viktorija | 22806 |
Sinkovič, Andreja | 18987 |
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