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  • Cyclic boronates as versatile scaffolds for KPC-2 ß-lactamase inhibition [Elektronski vir]
    Tooke, Catherine L. ...
    Klebsiella pneumoniae carbapenemase-2 (KPC-2) is a serine-β-lactamase (SBL) capable of hydrolysing almost all β-lactam antibiotics. We compare KPC-2 inhibition by vaborbactam, a clinically-approved ... monocyclic boronate, and VNRX-5133 (taniborbactam), a bicyclic boronate in late-stage clinical development. Vaborbactam inhibition is slowly reversible, whereas taniborbactam has an off-rate indicating essentially irreversible complex formation and a 15-fold higher on-rate, although both potentiate β-lactam activity against KPC-2-expressing K. pneumoniae. High resolution X-ray crystal structures reveal closely related binding modes for both inhibitors to KPC-2, with differences apparent only in positioning of the endocyclic boronate ester oxygen. The results indicate the bicyclic boronate scaffold as both an efficient, long-lasting, KPC-2 inhibitor and capable of supporting further iterations that may improve potency against specific enzyme targets and pre-empt the emergence of inhibitor resistant KPC-2 variants.
    Source: RSC medicinal chemistry [Elektronski vir]. - ISSN 2632-8682 (Letn. 11, št. 4, 10. jan. 2020, ilustr.)
    Type of material - e-article
    Publish date - 2020
    Language - english
    COBISS.SI-ID - 38244355

    Link(s):

    https://pubs.rsc.org/en/content/articlelanding/2020/md/c9md00557a/unauth#!divAbstract
    https://pubs.rsc.org/en/content/articlepdf/2020/md/c9md00557a
    DOI

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