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  • Characterization of naproxen-loaded solid SMEDDSs prepared by spray drying : the effect of the polysaccharide carrier and naproxen concentration
    Čerpnjak, Katja ...
    The purpose of this study was to prepare solid SMEDDS (sSMEDDS) particles produced by spray-drying using maltodextrin (MD), hypromellose (HPMC), and a combination of the two as a solid carrier. ... Naproxen (NPX) as the model drug was dissolved (at 6% concentration) or partially suspended (at 18% concentration) in a liquid SMEDDS composed of MiglyolŽ 812, Peceol, Gelucire 44/14, and Solutol HS 15. Among the sSMEDDSs tested, the MD-based sSMEDDSs (with a granular, smooth-surfaced, microspherical appearance) preserved the self-microemulsifying properties of liquid SMEDDSs and exhibited dissolution profiles similar to those of liquid SMEDDSs, irrespective of the concentration of NPX. In contrast, HPMC-based sSMEDDSs (irregular-shaped microparticles) exhibited slightly prolonged release times due to the polymeric nature of the carrier. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and Raman mapping analysis confirmed molecularly dissolved NPX (at 6% of drug loading), whereas at 18% NPX loading drug is partially molecularly dissolved and partially in the crystalline state.
    Source: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 485, iss. 1-2, 2015, str. 215-228)
    Type of material - article, component part ; adult, serious
    Publish date - 2015
    Language - english
    COBISS.SI-ID - 3832177

    Link(s):

    http://www.sciencedirect.com/science/article/pii/S0378517315002318
    DOI

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