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An overview of recent dipeptidyl peptidase-IV inhibitors : linking their structure and physico-chemical properties with SAR, pharmacokinetics and toxicitySmelcerović, Andrija ...Dipeptidyl peptidase-IV (DPP-IV) (EC 3.4.14.5) is a member of the broad class of hydrolytic enzymes which is responsible for degradation of the incretin peptide hormones regulating blood glucose ... levels. In this article we review the literature on natural and synthetic DPP-IV inhibitors, focusing their chemical structure and mechanism of action. Further, physico-chemical, pharmacokinetic and toxicological properties of DPP-IV inhibitors are calculated and compared. On the basis of literature data we selected the DPP-IV inhibitors with IC50 values below 1 nM and discussed their possible application in therapy of type 2 diabetes mellitus.Source: Current topics in medicinal chemistry. - ISSN 1568-0266 (Vol. 15, no. 23, 2015, str. 2342-2372)Type of material - article, component part ; adult, seriousPublish date - 2015Language - englishCOBISS.SI-ID - 3873649
source: Current topics in medicinal chemistry. - ISSN 1568-0266 (Vol. 15, no. 23, 2015, str. 2342-2372)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Smelcerović, Andrija | |
Miljković, Filip | |
Kolarević, Ana | |
Lazarević, Jelena, kemik | |
Djordjević, Aleksandra | |
Kocić, Gordana | |
Anderluh, Marko | 21456 |
Source: Personal bibliographies
and: SICRIS
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