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Antioxidant and anti-inflammatory properties of 1,2,4-oxadiazole analogs of resveratrolGobec, Martina, 1983- ...The chemopreventive properties of resveratrol are ascribed mostly to its antioxidant activity, in particular its scavenging ability for reactive oxygen species (ROS), and to the inhibition of NF-kB ... pathway which has also been suggested as an important underlying mechanism of its reported properties. In present study, a small library of nine 1,2,4-oxadiazole-based structural analogs of resveratrol were assayed for their antioxidant and anti-inflammatory activities. Several compounds showed significant inhibitory activities against NF-kB and/or ROS production. Compound 2, incorporating two para-hydroxyphenyl moieties connected by the 1,2,4-oxadiazole ring, was the most active, its potency in inhibiting activation of NF-kB and ROS scavenging abilities surpassing that of resveratrol. Additionally, we elucidated the mechanisms underlying the NFkB inhibitory activity of compound 2. Finally, in contrast to resveratrol, compound 2 significantly reduced the LPS-induced release of pro-inflammatory cytokines, indicating its prominent anti-inflammatory potential.Source: Chemico-biological interactions. - ISSN 0009-2797 (Vol. 240, Oct. 2015, str. 200-207)Type of material - article, component part ; adult, seriousPublish date - 2015Language - englishCOBISS.SI-ID - 3914865
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Gobec, Martina, 1983- | 32034 |
Tomašič, Tihomir | 28334 |
Markovič, Tijana | 34223 |
Mlinarič-Raščan, Irena | 12443 |
Sollner Dolenc, Marija | 08519 |
Jakopin, Žiga | 26496 |
Source: Personal bibliographies
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