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Farmakogenomika in bolniku prilagojena laboratorijska medicina = Pharmacogenomics and personalised laboratory medicineMarc, JanjaKončne definicije personalizirane medicine (bolniku prilagojene medicine) še nimamo. Ena od njih pravi, da je bolniku prilagojena medicina medicinski model, ki sloni na molekulskem profiliranju ... posameznika in omogoča izbor bolniku prilagojene (prave) terapije ob pravem času oziroma ugotavlja nagnjenost k bolezni ter uvaja preventivne, posamezniku prilagojene ukrepe ciljano in pravočasno. V pogenomskem obdobju je razvoj novih instrumentalnih tehnik in biostatističnih programov omogočil razvoj naprednih tehnologij >>omic<<. Te tehnologije omogočajo analizo celotne skupine kemijsko podobnih molekul kot je npr. genom, transkriptom, proteom, metabolom, epigenom, mikrobiom, itd. v nekem biološkem sistemu (tkivo, celica). Posebnost bolniku prilagojene (personalizirane) laboratorijske medicine je v tem, da se ne upirana spremembe v koncentraciji ene same molekule (diagnostičnega kazalca) temveč na spremembe profila molekul. Več kot je molekul, ki sestavljajo takšen profil bolj natančen je opis in več posebnosti stanja pri posameznika odraža - bolj je torej >>oseben<<. Od takšnega pristopa (medicinskega modela) si obetamo hitrejšo in učinkovitejšo diagnostiko ter boljše in varnejše zdravljenje s tem pa tudi hitrejše okrevanje in povrnitev zdravja. Bolniku prilagojena medicina v pravem pomenu predstavlja nov pristop k diagnostiki in terapiji, ki temelji na rezultatih naprednejših tehnologij >>omik<<. Stroka laboratorijske medicine se zaveda svoje vloge v bolniku prilagojeni medicini, vendar bo potrebno uvesti določene ukrepe in morda spremeniti organiziranost stroke ter predvsem povečati sodelovanje med posameznimi disciplinami znotraj laboratorijske medicine.Source: Raziskovalni dnevi laboratorijske biomedicine : zbornik predavanj (Str. 22-29)Type of material - conference contribution ; adult, seriousPublish date - 2015Language - slovenianCOBISS.SI-ID - 3952241
Author
Marc, Janja
Topics
napredne tehnologije omik |
genom |
proteom |
transkriptom |
metabolom |
diagnostični kazalec |
biooznačevalec
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Marc, Janja | 12189 |
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