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  • Clinical-pharmacist intervention reduces clinically relevant drug-drug interactions in patients with heart failure : a randomized, double-blind, controlled trial
    Roblek, Tina ...
    Background: Incidence of drug-drug interactions (DDIs) increases with complexity of treatment and comorbidities, as in heart failure (HF). This randomized, double-blind study evaluated the ... intervention of the pharmacist onprevalence of clinically relevant DDIs (NCT01855165). Methods: Patients admitted with HF were screened for clinically relevant DDIs, and randomized to control or intervention. All attending physicians received standard advice about pharmacological therapy; those in the intervention group also received alerts about clinically relevant DDIs. Primary endpoint was DDI at discharge and secondary were re-hospitalization or death during follow-up. Results: Of 213 patients, 51 (mean age, 79Ž6 years;male, 47%) showed 66 clinically relevant DDIs and were randomized. For intervention (n=26) versus control (n =25), the number of patients with and the number of DDIs were significantly lower at discharge: 8 vs. 18 and 10 vs. 31; p=0.003 and 0.0049, respectively. Over a 6 month follow-up period, 11 control and 9 intervention patients were re-hospitalized or died (p N 0.2 for all). No significant differences were seen between control and intervention for patients with eGFR b60 mL/min/1.73 m2 (78%) for re-hospitalization or death (10 vs. 7; p = 0.74). Conclusions: Pharmacist intervention significantly reduces the number of patients with clinically relevant DDIs, but not clinical endpoints 6 months from discharge.
    Source: International journal of cardiology. - ISSN 0167-5273 (Vol. 186, 15. Jan. 2016, str. 647-652)
    Type of material - article, component part
    Publish date - 2016
    Language - english
    COBISS.SI-ID - 3979889

    Link(s):

    http://www.sciencedirect.com/science/article/pii/S0167527315307701
    DOI

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