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A novel intestine model apparatus for drug dissolution capable of simulating the peristaltic action [Elektronski vir]Hribar, Melita ...A novel dissolution apparatus has been proposed as an alternative apparatus for dissolution testing. In this study, we evaluated the performance of the new intestine model for simulating the ... peristaltic action (IMSPA), generating the movement that closely mimics peristaltic contractions of the small intestine. Two polyethylene oxide matrix tablet formulations, containing a model drug belonging to class III of the Biopharmaceutics Classification System, were tested. Dissolution was also performed in the USP2 apparatus. The release profiles were further compared to the in vivo data to evaluate the in vivo relevance of the new apparatus. The results demonstrated that the novel apparatus showed good discriminatory power between different polyethylene oxide formulations. Moreover, a better relation to the in vivo data was established by the IMSPA as compared to the USP2 apparatus. In conclusion, the model parameters were efficiently controlled to ensure the dissolution conditions crucial for evaluating the in vivo release performance of the tested formulations.Source: AAPS PharmSciTech [Elektronski vir]. - ISSN 1530-9932 (Vol. 18, iss. 5, 2017, str. 1646-1656)Type of material - e-articlePublish date - 2017Language - englishCOBISS.SI-ID - 4225137
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hribar, Melita | 39315 |
Trontelj, Jurij | 23420 |
Klančar, Uroš | 33368 |
Markun, Boštjan | 23397 |
Čeligoj Dujc, Tanja | 20784 |
Legen, Igor | 20369 |
Source: Personal bibliographies
and: SICRIS
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