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Intracytoplasmatic sperm injection (ICSI) in infertility treatment : analysis of 3.339 consecutive cycles = Injiciranje spermatozoida u citoplazmu jajne stanice (ICSI) u liječenju neplodnosti : analiza 3.339 ciklusaKnez, Jure, dr. med., 1982- ; Vlaisavljević, Veljko ; Kovačič, BorutObjective. Introduction of intracytoplasmic sperm injection (ICSI) represented an important step in male infertility treatment. Today it is used in more than half of assisted reproductive procedures. ... Our aim was to investigate the paternal influence on ICSI procedure outcome. Methods. A total of 3.339 ICSI cycles were included in the retrospective analysis. After exclusion of female factor infertility related cycles, 919 cases remained for detailed analysis. Patients were classified according to sperm analysis and ICSI outcome was evaluated. Results. In 3.339 cycles, oocyte fertilization rate was 74 %. There were 1.134 clinical pregnancies (34 % per cycle) and 942 deliveries (28 % per cycle). Comparing ICSI with testicular spermatozoa to ICSI with ejaculated spermatozoa, lower fertilization rate (64 % vs. 73 %, p<0.05), blastulation rate (40 % vs. 53 %, p<0.05) and day 5 blastocyst transfer rate (65 % vs. 78 %, p<0.05) can be observed. Among the cycles using ejaculated spermatozoa, cryptozoospermia shows a negative effect on fertilization rate (50 %, p<0.05) and blastocyst development (43 %, p<0.05), but does not influence clinical pregnancy (44 %, p<0.05) and delivery rates (41 %, p<0.05). Conclusion. Very low sperm concentration and motility can predict low fertilization rate and slow embryo development after ICSI. The possibility of high quality embryo selection for transfer on day 5 allows high delivery rates in different groups of patients treated with ICSI using ejaculated or testicular spermatozoa.Source: Gynaecologia et Perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics. - ISSN 1330-0091 (Vol. 20, no. 2, Apr.-Jun. 2011, str. 65-71)Type of material - article, component part ; adult, seriousPublish date - 2011Language - englishCOBISS.SI-ID - 4301631
Author
Knez, Jure, dr. med., 1982- |
Vlaisavljević, Veljko |
Kovačič, Borut
Topics
Infertility, Male |
Moška neplodnost |
Sperm Injections, Intracytoplasmic |
Injiciranje semena, intracitoplazmično |
Sperm Motility |
Spermiji, gibljivost |
Fertilization in Vitro |
Oploditev in vitro |
Embryonic Development |
Zarodek, razvoj |
Treatment Outcome |
Izid zdravljenja
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Database name | Field | Year |
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Knez, Jure, dr. med., 1982- | 33092 |
Vlaisavljević, Veljko | 08996 |
Kovačič, Borut | 11040 |
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