ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Histamine (re)uptake by astrocytes : an experimental and computational studyPerdan-Pirkmajer, Katja ; Mavri, Janez ; Kržan, Mojca, 1962-Astrocytes participate in the clearance of neurotransmitters by their uptake and subsequent enzymatic degradation. Histamine as a polar and/orprotonated molecule must use a carrier to be transported ... across the cellmembrane, although a specific histamine transporter has not been elucidated, yet. In this work we upgraded the kinetic studies of histamine uptake into neonatal rat cultured type 1 astrocytes with quantum chemical calculations of histamine pKa values in conjunction with Langevin dipoles solvation model as the first step toward microscopic simulation of transport. Our results indicate that astrocytes transport histamine by at least two carrier mediated processes, a concentration gradient dependent passive and a sodium-dependent and ATP-driven active transport. We also demonstrated that histamine protonation states depend on the polarity of the environment. In conclusion wesuggest that histamine, a polar molecule atphysiological pH uses at least two different mechanisms for its uptakeinto astrocytes -an electrodiffusion and Na(+)-dependent and ouabain sensitive active process. We emphasize relevance of knowledge ofhistamines protonation states at the rate limiting step of its transport for microscopic simulation that will be possible when structure of histamine transporter is known.Source: Journal of molecular modeling. - ISSN 1610-2940 (Letn. 6, št. 1, 2010, str. 1151-1158)Type of material - article, component partPublish date - 2010Language - englishCOBISS.SI-ID - 4319258
Author
Perdan-Pirkmajer, Katja |
Mavri, Janez |
Kržan, Mojca, 1962-
Topics
fizikalna kemija |
biokemija |
histamin |
astrociti |
nevrologija |
kinaze
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Perdan-Pirkmajer, Katja | 29467 |
Mavri, Janez | 08611 |
Kržan, Mojca, 1962- | 08095 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: