ALL libraries (COBIB.SI union bibliographic/catalogue database)
  • Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease [Elektronski vir]
    Knez, Damijan, farmacevt ...
    Accumulating evidence indicates a solid relationship between several enzymes and Alzheimer's disease. Cholinesterases and monoamine oxidases are closely associated with the disease symptomatology and ... progression and have been tackled simultaneously using several multifunctional ligands. This design strategy offers great chances to alter the course of Alzheimer's disease, in addition to alleviation of the symptoms. More than 15 years of research has led to the identification of various dual cholinesterase/monoamine oxidase inhibitors, while some showing positive outcomes in clinical trials, thus giving rise to additional research efforts in the field. The aim of this review is to provide an update on the novel dual inhibitors identified recently and to shed light on their therapeutic potential.
    Source: Future medicinal chemistry. - ISSN 1756-8919 (Vol. 9, no. 8, 2017, Str. 811-832)
    Type of material - e-article
    Publish date - 2017
    Language - english
    COBISS.SI-ID - 4329841

    Link(s):

    http://www.future-science.com/doi/abs/10.4155/fmc-2017-0036
    DOI

Shelf entry