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Clustering of protein transmembrane regions using chemometric tools [Elektronski vir]Roy Choudhury, Amrita ; Novič, MarjanaPredlagamo uporabo kemometrijskega pristopa za analizo in grupiranje transmembranskih segmentov proteinov, javno dostopnih v internetnih podatkovnih bazah. Različne segmente proteinov, predstavljenih ... v obliki matematičnih deskriptorjev proteinskih sekvenc, preslikamo v 2D mapo s pomočjo Kohonenove nevronske mreže, tako da se segmenti sami organizirajo v različne skupine glede na določene lastnosti. V nadaljevanju je prikazano, da lahko uporabimo Kohonenove mape za grupiranje transmembranskih segmentov glede na funkcionalno klasifikacijo transmembranskih proteinov. Ker je strukturna in funkcijska analiza transmembranskih proteinov zapletena in težko rešljiva problematika, je efektivno grupiranje transmembranskih segmentovna osnovi informacije o proteinski sekvenci z uporabo kemometrijskih metod lahko v pomoč pri razumevanju transmembranskih proteinov.Source: Slovenski kemijski dnevi 2009, Maribor, 24. in 25. september 2009 [Elektronski vir] (5 str.)Type of material - conference contributionPublish date - 2009Language - englishCOBISS.SI-ID - 4377370
Author
Roy Choudhury, Amrita |
Novič, Marjana
Topics
kohonen maps |
transmembrane regions |
clustering
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Roy Choudhury, Amrita | 30840 |
Novič, Marjana | 09775 |
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