ALL libraries (COBIB.SI union bibliographic/catalogue database)
  • Inhibition of D-Ala [Elektronski vir] : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
    Batson, Sarah ...
    D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase. By a combination of structural, ... chemical and mechanistic studies here we show that the inhibition of D-alanine:D-alanine ligase by the antibiotic D-cycloserine proceeds via a distinct phosphorylated form of the drug. This mechanistic insight reveals a bimodal mechanism of action for a single antibiotic on different enzyme targets and has significance for the design of future inhibitor molecules based on this chemical structure.
    Source: Nature communications [Elektronski vir]. - ISSN 2041-1723 (Vol. 8, Dec. 2017, str. 1-7)
    Type of material - e-article
    Publish date - 2017
    Language - english
    COBISS.SI-ID - 4444273