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Recent progress in the discovery and development of DNA gyrase B inhibitors [Elektronski vir]Barančokova, Michaela ; Kikelj, Danijel ; Ilaš, JanezNew antibacterials that modulate less explored targets are needed to fight the emerging bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search. These are both ... type II topoisomerases that can cleave both DNA strands, and can thus alter DNA topology during replication or similar processes. Currently, there are no ATP-competitive inhibitors of these two enzymes on the market, as the only aminocoumarin representative, novobiocin, was withdrawn due to safety concerns. The search for novel ATP-competitive inhibitors is a focus of ongoing industrial and academical research. This review summarizes the recent efforts in the design, synthesis and evaluation of GyrB/ParE inhibitors. The various approaches to achieve improved antibacterial activities are described, with particular reference to Gram-negative bacteria.Source: Future medicinal chemistry. - ISSN 1756-8919 (Vol. 10, no. 10, 2018, str. 1207-1227)Type of material - e-articlePublish date - 2018Language - englishCOBISS.SI-ID - 4515441
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Barančokova, Michaela | 39784 |
Kikelj, Danijel | 01463 |
Ilaš, Janez | 24400 |
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and: SICRIS
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