ALL libraries (COBIB.SI union bibliographic/catalogue database)
PDF
  • Design and development of Nrf2 modulators for cancer chemoprevention and therapy : a review
    Sova, Matej, 1979- ; Saso, Luciano
    A major cell defense mechanism against oxidative and xenobiotic stress is mediated by the Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many cytoprotective and ... detoxifying enzymes, thus playing a pivotal role in maintaining redox cellular homeostasis. Many diseases including cancer have been closely related to impaired Nrf2 activity. Targeting Nrf2 and modulating its activity represents a novel modern strategy for cancer chemoprevention and therapy. In this review, different design strategies used for the development of Nrf2 modulators are described in detail. Moreover, the main focus is on important and recently developed Nrf2 activators and inhibitors, their in vitro and in vivo studies, and their potential use as chemopreventive agents and/or cancer therapeutics.
    Source: Drug design, development and therapy [Elektronski vir]. - ISSN 1177-8881 (Vol. 2018:12, Sep. 2018, str. 3181-3197)
    Type of material - article, component part
    Publish date - 2018
    Language - english
    COBISS.SI-ID - 4602737

    Link(s):

    https://www.dovepress.com/articles.php?article_id=40891

    Prost dostop


    DOI

Shelf entry