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The pore-forming action of polyenes : from model membranes to living organismsKristanc, Luka ...The incidence of resistant fungal pathogens has been increasing, especially in immuno-compromised people. As such, considerable research has been focused on discovering anti-fungal agents with new ... mechanisms of action and on optimizing the use of existing agents. In this context, interest in the polyene group of anti-fungals has recently been renewed, since they are known to be effective against a broad spectrum of fungal pathogens that only rarely develop a resistance to them. In the past 10 years considerable efforts have been made to improve their efficacy and, simultaneously, to reduce their toxicity. Knowledge about the basic mechanisms of their action will be of crucial importance to further optimizing their use. The mechanisms of polyene action at the membrane level are reviewed here, focusing primarily on their pore-forming activity and on the resulting osmotic responses of artificial lipid vesicles and different eukaryotic cells.Source: Biochimica et biophysica acta. Biomembranes. - ISSN 0005-2736 (Vol. 1861, iss. 2, 2019, str. 418-430)Type of material - article, component partPublish date - 2019Language - englishCOBISS.SI-ID - 4634737
Author
Kristanc, Luka |
Božič, Bojan, 1965- |
Zemljič Jokhadar, Špela |
Sollner Dolenc, Marija |
Gomišček, Gregor
Topics
Patogeni |
polyenes |
sterols |
pore forming |
tension pore |
osmotic stress |
polieni |
steroli |
tvorjenje por |
tenzijska pora |
osmotski stres
source: Biochimica et biophysica acta. Biomembranes. - ISSN 0005-2736 (Vol. 1861, iss. 2, 2019, str. 418-430)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kristanc, Luka | 34753 |
Božič, Bojan, 1965- | 11088 |
Zemljič Jokhadar, Špela | 26234 |
Sollner Dolenc, Marija | 08519 |
Gomišček, Gregor | 18038 |
Source: Personal bibliographies
and: SICRIS
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