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Vloga cisteinske peptidaze katepsina X v glioblastomskih matičnih celicah = The role of cysteine peptidase cathepsin X in glioblastoma stem cellsffold : magistrska naloga : enovit magistrski študij farmacijaBionda, GregorGlioblastomske matične celice (GMC) so majhna populacija slabo diferenciranih celic, prisotna v multiformnem glioblastomu (GBM), eni izmed oblik možganskega tumorja. Imajo samoobnovitveni potencial ... in so se sposobne diferencirati v različne vrste tumorskih celic. Odporne so na vse oblike zdravljenja in tako vedno ostane majhen delež teh celic, ki so odgovorne za ponovno rast tumorja. Zato bi bila za uspešno terapijo glioblastoma potrebna odstranitev prav vseh GMC. K invazivnosti in celični migraciji glioblastomskih celic prispeva izražanje in delovanje cisteinske karboksi peptidaze katepsina X, ki ima pomembno vlogo pri tumorski progresiji. V magistrski nalogi smo na glioblastomski celični liniji U87 želeli ovrednotiti vlogo katepsina X v celicah, podobnim glioblastomskim matičnim celicam (GSCs). Celice U87 so sposobne tvorbe tridimenzionalnih celičnih skupkov, t.i. sferoidov, s katerimi se zaščitijo pred stimulusi iz okolja. Naši rezultati so pokazali, da s stimulacijo celic U87 dosežemo ekspanzijo celic GSCs. Hkrati smo v teh celicah pokazali povečano izražanje katepsina X, ki predstavlja možno novo tarčo pri obravnavanju zdravljenja GBM. V zadnjem delu magistrske naloge smo opazovali ekspanzijo celic GSCs ob prisotnosti specifičnega zaviralca katepsina X. Pri tem smo pokazali, da zaviranje katepsina X pomembno vpliva na ekspanzijo celic GSCs. Iz zbranih rezultatov lahko sklepamo o pomembnosti katepsina X v GMC, hkrati pa vidimo da bi uravnavanje proteaze v teh celicah lahko vodilo v nove možnosti zdravljenja GBM.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [G. Bionda], 2019Language - slovenianCOBISS.SI-ID - 4685681
Author
Bionda, Gregor
Other authors
Pišlar, Anja
Topics
Glioblastom |
multiformni glioblastom |
glioblastomske matične celice |
katepsin X |
ireverzibilni zaviralec |
stimulacije celic U87
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bionda, Gregor | |
Pišlar, Anja | 32035 |
Source: Personal bibliographies
and: SICRIS
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