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Morphometrical analysis of the p53 tissue marker in prostatic adenocarcinoma and its relationship to Gleason score and PSA level = Morfometrična analiza tkivnega označevalca p53 v adenokarcinomu prostate v povezavi z oceno po Gleasonu in vrednostjo PSAMunda, Miha, 1970- ...Namen: Rak prostate je v svetu zelo pogosta maligna bolezen. K natančnejši oceni bolezni bi lahko pripomogli tkivni označevalci, kot je na primer tudi p53. V vzorcih adenokarcinoma prostate slovenske ... populacje smo morfometrično analizirali izražanje p53 in njegovo povezavo z oceno po Gleasonu in vrednostjo PSA ter starostjo bolnikov. Metode: V retrospektivno pilotno študijo smo vključili 25 bolnikov z opravljeno radikalno prostatektomijo. Tkivni označevalec p53 smo določili imunohistokemično in ga izrazili kot indeks p53. Statistično smo poiskali povezave indeksa p53 z oceno po Gleasonu pred in po operaciji, vrednostjo PSA in starostjo bolnikov. Rezultati: Tkivni označevalec p53 je v raku prostate neenakomerno porazdeljen neodvisno od lokalnega Gleason vzorca, vendar korelira z oceno po Gleasonu po operaciji in mejno korelira z vrednostjo PSA. Statistično značilno so med seboj povezani tudi ocena po Gleasonu pred in po operaciji, vrednost PSA in starost bolnika. Zaključek: Potrdili smo, da ima p53 lahko napovedno vrednost kljub manjšemu številu primerov, vključenih v to raziskavo. Rezultati pilotne študije kažejo, da je p53 obetajoč tkivni označevalec in bi lahko bil uporaben kot dodatni diagnostični parameter.Source: Acta medico-biotechnica : AMB. - ISSN 1855-5640 (Vol. 6, [no.] 1, 2013, str. 59-64)Type of material - article, component part ; adult, seriousPublish date - 2013Language - englishCOBISS.SI-ID - 4710463
Author
Munda, Miha, 1970- |
Dariš, Barbara |
Hajdinjak, Tine |
Kavalar, Rajko |
Štiblar-Martinčič, Draga
Topics
rak (medicina) |
prostata |
tkivni označevalci |
p53 |
imunohistokemija
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Munda, Miha, 1970- | 30807 |
Dariš, Barbara | 26446 |
Hajdinjak, Tine | 19105 |
Kavalar, Rajko | 10772 |
Štiblar-Martinčič, Draga | 07798 |
Source: Personal bibliographies
and: SICRIS
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