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Serum Klotho as a marker for early diagnosis of acute kidney injury after cardiac surgery : Serumski Klotho kao marker za ranu dijagnozu akutnog oštetećenja bubrega nakon operacije srcaJerin, Aleš ...Background: Early diagnosis of acute kidney injury (AKI) after cardiac surgery is based on serum creatinine which is neither a specific nor a sensitive biomarker. In our study, we investigated the ... role of serum Klotho in early prediction of AKI after cardiac surgery using cardiopulmonary bypass (CPB). Methods: The included patients were classified into three groups according to AKI stages using KDIGO criteria. The measurements of creatinine and Klotho levels in serum were performed before surgery, at the end of CPB, 2 hours after the end of CPB, 24 hours and 48 hours postoperatively. Results: Seventy-eight patients were included in the study. A significant increase of creatinine levels (p<0.001) was measured on the first day after the surgery in both AKI groups compared to the non-AKI group. However, a significant difference between AKI-2 and AKI-1 groups (p=0.006) was not measured until the second day after the operation. Using decision trees for classification of patients with a higher or lower risk of AKI we found out that Klotho discriminated between the patients at low risk of developing more severe kidney injury in the first hours after surgery and the patients at high risk better than creatinine. Adding also the early measurements of creatinine in the decision tree model further improved the prediction of AKI. Conclusions: Serum Klotho may be useful to discriminate between the patients at lower and the patients at higher risk of developing severe kidney injury after cardiac surgery using CPB already in the first hours after surgery.Source: Journal of Medical Biochemistry. - ISSN 1452-8258 (Vol. 39, br. 2, 2020, str. 133-139)Type of material - article, component part ; adult, seriousPublish date - 2020Language - englishCOBISS.SI-ID - 4749937
Author
Jerin, Aleš |
Mosa Fathy, Osama |
Kališnik, Jurij-Matija |
Žibert, Janez, 1974- |
Skitek, Milan
Topics
Holesterol |
Ateroskleroza |
akutne poškodbe ledvic |
operacija srca |
kreatinin |
Klotho
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jerin, Aleš | 17160 |
Mosa Fathy, Osama | |
Kališnik, Jurij-Matija | 21172 |
Žibert, Janez, 1974- | 19236 |
Skitek, Milan | 11331 |
Source: Personal bibliographies
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