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''In vitro'' mucoadhesion of mesoporous silicon microparticles [Elektronski vir]
Grande López-Jurado, Isabel
The purpose of the present thesis was to evaluate the mucoadhesion to gastrointestinal (GI) tract tissue of different mesoporous silicon microparticles dispersed in different media, by measuring the ...percentage of intestinal area covered by microparticles in vitro. First, using Sweetana-Grass diffusion chambers, rat GI tract tissue samples were exposed to thermally carbonized porous silicon microparticles (TCPSi), thermally carbonized porous silicon rounded (TCPSi R) or thermally carbonized non-porous silicon microparticles (TC-non-Psi), suspended in different media to emulate the critical conditions necessary for the attachment of microparticles. Then, with the stereomicroscope, the tissue was visualized at different magnifications (6,25; 20 and 45). With the 45 magnification picture, the percentage of intestinal area covered by microparticles was measured by using the Cellsense program. Finally, that data was collected in a MS Excel document and in SPSS, it was Statistically analysed (normality, student T-test and Post-Hoc Dunnett's test). Obtained results confirmed that the mucoadhesion of the mesoporous microparticles was good enough regardless the media where the microparticles were dispersed, the porosity of the microparticles, the removal of the tissue mucus layer with a solution with cysteine or an increase in the washing out period. The last two points showing that the microparticles% mucoadhesive polymers have good affinity to the mucosa itself and don%t need mucus for it. Moreover, the results showed that the mucoadhesion of the microparticles depend on the shape, showing a greater intestinal area covered by TCPSi R (%), than that of TCPSi.
Type of material - master's thesis
; adult, serious
Publication and manufacture - Ljubljana : [I. Grande López-Jurado], 2018
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