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Direct determination of the base-pair force constant of DNA from the acoustic phonon dispersion of the double helixVan Eijck, L. ...Quantifying the molecular elasticity of DNA is fundamental to our understanding of its biological functions. Recently different groups, through experiments on tailored DNA samples and numerical ... models, have reported a range of stretching force constants (0.3 to 3 N/m). However, the most direct, microscopic measurement of DNA stiffness is obtained from the dispersion of its vibrations. A new neutron scattering spectrometer and aligned, wet spun samples have enabled such measurements, which provide the first data of collective excitations of DNA and yield a force constant of 83 N/m. Structural and dynamic order persists unchanged to within 15 K of themelting point of the sample, precluding the formation of bubbles. These findings are supported by large scale phonon and molecular dynamics calculations, which reconcile hard and soft force constants.Source: Physical review letters. - ISSN 0031-9007 (Vol. 107, iss. 8, 2011, str. 088102-1-088102-5)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 4758298
Author
Van Eijck, L. |
Merzel, Franci |
Rols, S. |
Ollivier, Jacques |
Forsyth, V. T. |
Johnson, Mark R.
Topics
strukturna kemija |
DNA |
delovanje celic
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Van Eijck, L. | ![]() |
Merzel, Franci | 13627 |
Rols, S. | ![]() |
Ollivier, Jacques | ![]() |
Forsyth, V. T. | ![]() |
Johnson, Mark R. | ![]() |
Source: Personal bibliographies
and: SICRIS
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