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Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis [Elektronski vir]Kodrič, Klemen, biomedicinec ...Receptor activator of nuclear factor kappaB ligand (RANKL) plays a crucial role in bone metabolism. RANKL gene misregulation has been implicated in several bone and cancer diseases. Here, we aimed to ... identify novel transcription regulators of RANKL expression. We discovered that transcription factors, sex-determining region Y (SRY) and c-Myb, regulate RANKL expression. We demonstrated that c-Myb increases and male-specific SRY decreases RANKL expression through direct binding to its 5'-proximal promoter. These results are corroborated by the gene expression in human bone samples. In osteoporotic men, expression of RANKL is 17-fold higher, which correlates with the drastically reduced expression (200-fold) of Sry, suggesting that in osteoporotic men, the upregulation of RANKL is caused by a decrease of Sry. In healthy men, the expression of RANKL is 20% higher than that in healthy women. Our data suggest that gender differences in RANKL expression and bone quality could be due to the sex-specific transcription factor SRY.Source: Experimental and molecular medicine. - ISSN 2092-6413 (Vol. 51, no. 8, Aug. 2019, str. 1-16)Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 4766321
Author
Kodrič, Klemen, biomedicinec |
Zupan, Janja, farmacevtka |
Kranjc, Tilen |
Komadina, Radko |
Mlakar, Vid |
Marc, Janja |
Lovšin, Nika
Topics
Osteoporoza |
Sarkom |
RANKL |
SRY protein
Author | Kodrič, Klemen, biomedicinec ... |
Title | Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis [Elektronski vir] |
Publication date | 2019-08-28 |
COBISS.SI-ID | 4766321 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Odkrivanje novih regulatorjev izražanja RANKL, ključne molekule ne samo v kostni prenovi | J3-7245-2016 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://www.nature.com/articles/s12276-019-0294-3 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=141292 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kodrič, Klemen, biomedicinec | 38167 |
Zupan, Janja, farmacevtka | 32306 |
Kranjc, Tilen | 33053 |
Komadina, Radko | 19380 |
Mlakar, Vid | 25809 |
Marc, Janja | 12189 |
Lovšin, Nika | 19649 |
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