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UNC93B1 direct TLR3 towards the the[!] cell membrane
Pohar, Jelka, 1984- ...
Toll-like receptors (TLRs) are involved in recognition of a variety of molecules or microbial origin. UNC93B1 is indispensable for signalling of nucleotide-sensing toll-like receptors. UNC93B1 ...physically interacts with intracellular TLRs in the endoplasmic reticulum and supports their trafficking to endolysosomes. Deficiency in UNC93B1 causes severe effects on the recognition of nucleic acids and pathogens both in humans and mice. We observed that overexpression of UNC93B1 elevates the abundance of TLR3, but not TLR9, at the surface of the plasma membrane. UNC93B1 also led to upregulation of TLR3 expression. It has been reported that TLR3 and TLR9 interact with UNC93B1 via their transmembrane segments. In order to study the importance of these segments for different localization of TLR3 and TLR9, we prepa red chimeric constructs, where the transmembrane segments of TLR3 and have been exchanged. UNB93B1 nevertheless delivered TLR3, whose transmembrane segment has been repalcedwith TLR9 to the celi surface, demonstrating that luminal or cytoplasmic domain govern interaction of TLR3 with UNC93B1. Physiological role of surface TLR3 observed in epithelial cells will be investigated.
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