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THP-1 cells and pro-inflammatory cytokine productionTHP-1 Cells and pro-inflammatory cytokine production [Elektronski vir] : an in vitro tool for functional characterization of NOD1/NOD2 antagonistsJakopin, Žiga ; Corsini, Emanuela, pharmacistTHP-1 cells express high levels of native functional nucleotide-binding oligomerization domain 1 (NOD1), NOD2, and Toll-like receptor 4 (TLR4) receptors, and have often been used for investigating ... the immunomodulatory effects of small molecules. We postulated that they would represent an ideal cell-based model for our study, the aim of which was to develop a new in vitro tool for functional characterization of NOD antagonists. NOD antagonists were initially screened for their effect on NOD agonist-induced interleukin-8 (IL-8) release. Next, we examined the extent to which the selected NOD antagonists block the NOD-TLR4 synergistic crosstalk by measuring the effect of NOD antagonism on tumor necrosis factoralpha - (TNF-alpha) secretion from doubly activated THP- 1 cells. Overall, the results obtained indicate that pro-inflammatory cytokine secretion from THP-1 provides a valuable, simple and reproducible in vitro tool for functional characterization of NOD antagonists.Source: International journal of molecular sciences [Elektronski vir]. - ISSN 1422-0067 (Vol. 20, no. 17, 2019, str. 1-11)Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 4770417
Author
Jakopin, Žiga |
Corsini, Emanuela, pharmacist
Topics
Citokini |
Imunomodulatorji |
THP-1 |
cytokines |
IL-8 |
TNF-alpha |
immunomodulation |
NOD1 antagonist |
NOD2 antagonist |
functional characterization
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jakopin, Žiga | 26496 |
Corsini, Emanuela, pharmacist |
Source: Personal bibliographies
and: SICRIS
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